data analysis & event prediction in diabetes
use of Recurrent Neural Networks / Convolutional Neural Networks to extract information from time-series data in diabetes to allow regression / classification analysis. Applications include prediction of mortality from HbA1c time series analysis, prediction of inpatient outcomes from pre-admission data and individualised virtual n=1 drug trials to allow optimum drug selection
Current
Onboarding information here
Previous
2023 Clarissa Gardner, Deborah Wake, Doogie Brodie, Alex Silverstein, Sophie Young, Scott Cunningham, Chris Sainsbury, Maria Ilia, Amanda Lucas, Tony Willis, Jack Halligan. Evaluation of prototype risk prediction tools for clinicians and people living with type 2 diabetes in North West London using the think aloud method. https://doi.org/10.1177/20552076221128677
2023 A Subramanian, K Gokhale, C Sainsbury, K Nirantharakumar, KA Toulis. Sodium-glucose cotransporter-2 inhibitors and the risk of gout in patients with type 2 diabetes mellitus: A propensity-score-matched, new-user design study with an active comparator using the IQVIA Medical Research Data UK database. 2022. Diabetes, Obesity and Metabolism. https://doi.org/10.1111/dom.14858
2022 Risk of progression from pre‐diabetes to type 2 diabetes in a large UK adult cohort. MP Gardner, J Wang, JM Hazlehurst, C Sainsbury, J Blissett, K Nirantharakumar, N Thomas, S Bellary. 2022. Risk of progression from pre‐diabetes to type 2 diabetes in a large UK adult cohort. Diabetic medicine. https://doi.org/10.1111/dme.14996
2022 Greenwood, David, Thomas Taverner, Nicola J. Adderley, Malcolm James Price, Krishna Gokhale, Christopher Sainsbury, Suzy Gallier, et al. 2022. “Machine Learning of COVID-19 Clinical Data Identifies Population Structures with Therapeutic Potential.” iScience 25 (7): 104480.
2022 Wang, Zhaonan, Jonathan Hazlehurst, Anuradhaa Subramanian, Abd A. Tahrani, Wasim Hanif, Neil Thomas, Pushpa Singh, et al. 2022. “Diabetic Foot Risk Classification at the Time of Type 2 Diabetes Diagnosis and Subsequent Risk of Mortality: A Population-Based Cohort Study.” Frontiers in Endocrinology 13 (July): 888924.
2022 Gokhale, Krishna, Samiul A. Mostafa, Jingya Wang, Abd A. Tahrani, Christopher Andrew Sainsbury, Konstantinos A. Toulis, G. Neil Thomas, et al. 2022. “The Clinical Profile and Associated Mortality in People with and without Diabetes with Coronavirus Disease 2019 on Admission to Acute Hospital Services.” Endocrinology, Diabetes & Metabolism 5 (1): e00309.
2022 Adderley, Nicola J., Thomas Taverner, Malcolm James Price, Christopher Sainsbury, David Greenwood, Joht Singh Chandan, Yemisi Takwoingi, et al. 2022. “Development and External Validation of Prognostic Models for COVID-19 to Support Risk Stratification in Secondary Care.” BMJ Open 12 (1): e049506.
2021 Haroon, Shamil, Anuradhaa Subramanian, Jennifer Cooper, Astha Anand, Krishna Gokhale, Nathan Byne, Samir Dhalla, et al. 2021. “Renin-Angiotensin System Inhibitors and Susceptibility to COVID-19 in Patients with Hypertension: A Propensity Score-Matched Cohort Study in Primary Care.” BMC Infectious Diseases 21 (1): 262.
2021 Subramanian, Anuradhaa, Astha Anand, Nicola J. Adderley, Kelvin Okoth, Konstantinos A. Toulis, Krishna Gokhale, Christopher Sainsbury, Michael W. O’Reilly, Wiebke Arlt, and Krishnarajah Nirantharakumar. 2021. “Increased COVID-19 Infections in Women with Polycystic Ovary Syndrome: A Population-Based Study.” European Journal of Endocrinology / European Federation of Endocrine Societies 184 (5): 637–45.
2021 Association of metformin with susceptibility to COVID-19 in people with Type 2 diabetes. J Wang, J Cooper, K Gokhale, D Acosta-Mena, S Dhalla, N Byne, J Singh Chandan, A Anand, K Okoth, A Subramanian, MN Bangash, T Jackson, D Zemedikun, T Taverner, W Hanif, S Ghosh, P Narendran, K Toulis, A Tahrani, R Surenthirakumaran, NJ Adderley, S Haroon, K Khunti, C Sainsbury, GN Thomas, K Nirantharakumar. The Journal of Clinical Endocrinology & Metabolism. 2021. web
2021 Development and external validation of prognostic models for COVID-19 to support risk stratification in secondary care. Nicola J Adderley, Thomas Taverner, Malcolm Price, Christopher Sainsbury, David Greenwood, Joht Singh Chandan, Yemisi Takwoingi, Rashan Haniffa, Isaac Hosier, Carly Welch, Dhruv Parekh, Suzy Gallier, Krishna M Gokhale, Alastair K Denniston, Elizabeth Sapey, Krishnarajah Nirantharakumar. Preprint. Medrxiv. 30 Jan 2021. web
2021 Social Deprivation and Incident Diabetes-Related Foot Disease in Patients With Type 2 Diabetes: A Population-Based Cohort Study. Jenny Riley, Christina Antza, Punith Kempegowda, Anuradhaa Subramanian, Joht Singh Chandan, Krishna Gokhale, Neil Thomas, Christopher Sainsbury, Abd A. Tahrani, Krishnarajah Nirantharakumar. Diabetes Care. 2021. https://doi.org/10.2337/dc20-1027 web
2020 Non‐steroidal anti‐inflammatory drugs and susceptibility to COVID‐19. Joht Singh Chandan, Dawit Tefra Zemedikun, Rasiah Thayakaran, Nathan Byne, Samir Dhalla, Dionisio Acosta‐Mena, Krishna M Gokhale, Tom Thomas, Christopher Sainsbury, Anuradhaa Subramanian, Jennifer Cooper, Astha Anand, Kelvin O Okoth, Jingya Wang, Nicola J Adderley, Thomas Taverner, Alastair K Denniston, Janet Lord, G. Neil Thomas, Christopher D Buckley, Karim Raza, Neeraj Bhala, Krishnarajah Nirantharakumar, Shamil Haroon. Arthritis and Rheumatology. 2020. https://doi.org/10.1002/art.41593 web
2020 Sodium‐glucose‐co‐transporter‐2 inhibitors and susceptibility to COVID‐19: a population‐based retrospective cohort study. C Sainsbury, J Wang, K Gokhale, D Acosta‐Mena, S Dhalla, N Byne, J Singh Chandan, A Anand, J Cooper, K Okoth, A Subramanian, M Bangash, T Taverner, W Hanif, S Ghosh, P Narendran, KK Cheng, Tom Marshall, G Gkoutos, K Toulis PhD, GN Thomas PhD, A Tahrani, N Adderley, S Haroon, K Nirantharakumar. Diabetes Obesity and Metabolism 2020. https://doi.org/10.1111/dom.14203 web
2020 Renin-angiotensin system inhibitors and susceptibility to COVID-19 in patients with hypertension: a propensity score-matched cohort study in primary care. S Haroon,A Subramanian,J Cooper, A Anand, K Gokhale, N Byne, S Dhalla, D Acosta-Mena, T Taverner, K Okoth, J Wang, J Singh Chandan, C Sainsbury, D Zemedikun, GN Thomas,D Parekh, T Marshall, E Sapey, NJ Adderley, K Nirantharakumar. Preprint. Medrxiv. 18 Sep 2020. web
2020 Remodelling diabetes services and emerging innovation. DJ Wake, FW Gibb, P Kar, B Kennon, DC Klonoff, G Rayman, MK Rutter, C Sainsbury, RK Semple. European Journal of Endocrinology 183 (2). web
2020 Obstructive Sleep Apnea, a Risk Factor for Cardiovascular and Microvascular Disease in Patients With Type 2 Diabetes: Findings From a Population-Based Cohort StudyNJ Adderley, A Subramanian, K Toulis, K Gokhale, T Taverner, W Hanif, S Haroon, GN Thomas, C Sainsbury, AA Tahrani, K Nirantharakumar. Diabetes Care | https://doi.org/10.2337/dc19-2116 | web
2019 Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study. R Thayakaran, NJ Adderley, C Sainsbury, B Torlinska, K Boelaert, D Šumilo, M Price, GN Thomas, KA Toulis, K Nirantharakumar. BMJ 2019; 366 | https://doi.org/10.1136/bmj.l4892 | web
2018 Admission Glucose Number (AGN): A point of admission score associated with inpatient glucose variability, hypoglycaemia and mortality. J McKechnie, R Maitland, CAR Sainsbury, GC Jones. Journal of Diabetes Science and Technology | https://doi.org/10.1177/1932296818800722 | web
2018 Identifying modifiable risk factors to reduce inpatient hypoglycaemia. PD Murray, BA McKee, CAR Sainsbury, GC Jones. Clinical Pharmacist, August 2018, Vol 10, No 8, online | DOI: 10.1211/CP.2018.20205227 | web
2018 Structured education using Dose Adjustment for Normal Eating (DAFNE) reduces long term HbA1c and HbA1c variability. GS Walker, JY Chen, H Hopkinson, CAR Sainsbury, GC Jones. 2018. Diabetic Medicine | web
2018 Visit-to-visit HbA1c variability and systolic blood pressure (SBP) variability are significantly and additively associated with mortality in people with type 1 diabetes: an observational study. Stuart S. Wightman, Christopher A.R. Sainsbury, Gregory C. Jones. Diabetes Obesity & Metabolism | web
2017 HbA1c variability is associated with increased mortality and earlier hospital admission in people with type 1 diabetes. Graham S Walker, Scott G Cunningham, Christopher A.R. Sainsbury, Gregory C. Jones. Diabetic Medicine | web
2017 A practical review of C-Peptide Testing in Diabetes. E Leighton, C Sainsbury, G Jones. Diabetes Ther | web | .pdf
2017 Hypoglycemia and Clinical Outcomes in Hospitalized Patients With Diabetes: Does Association With Adverse Outcomes Remain When Number of Glucose Tests Performed Is Accounted For? GC Jones, JG Timmons, SG Cunningham, SJ Cleland, CAR Sainsbury Journal of Diabetes Science and Technology | web | .pdf
2016 A Practical Approach to Glucose Abnormalities in Cystic Fibrosis GC Jones, CAR Sainsbury | web | .pdf
2016 Is all hypoglycaemia treated as equal? An observational study of how the type of diabetes and treatment prescribed prior to admission influences quality of treatment of inpatient hypoglycaemia GC Jones, J Khan, CAR Sainsbury | web | .pdf
2016 Stroke and diabetes: a dangerous liaison SL Macpherson, C Sainsbury, J Dawson, GC Jones | web | .pdf
2016 Living with asthma and chronic obstructive airways disease: using technology to support self-management – an overview. D Morrison,FS Mair, L Yardley, S Kirby, M Thomas | web
2016 Patterns and impact of hypoglycemia, hyperglycemia, and glucose variability on inpatients with insulin-treated cystic fibrosis-related diabetes GC Jones, ZM Chong, J Gilmour, C Matheson, G MacGregor, C Sainsbury | web | .pdf
2016 Metformin increases cortisol regeneration by 11βHSD1 in obese men with and without type 2 diabetes mellitus Anderson AJ, Andrew R, Homer NZ, Jones GC, Smith K, Livingstone DE, Walker BR, Stimson RH | web
2016 Inpatient glycemic variability and long-term mortality in hospitalized patients with type 2 diabetes JG Timmons, SG Cunningham, CAR Sainsbury, GC Jones Journal of Diabetes and its Complications
2016 Evaluation of a combination of SGLT2 inhibitor and GLP-1 receptor agonist treatment in type 2 diabetes Hayden J, Huang F, McConnell LMJ, Sainsbury CAR, Jones GC Diabetes & Primary Care 18 (3): 135-138
2016 Managing multimorbidity in primary care in patients with chronic respiratory conditions. npj Primary Care Respiratory Medicine, 26, 16043. D Morrison,K Agur, S Mercer, A Eiras, JI González-Montalvo, K Gruffydd-Jones Primary Care Respiratory Medicine, 26, 16043
2016 Experience of and predictors of response to dapagliflozin in a real-life cohort of people with type 2 diabetes Huang F, Hayden J, McConnell LMJ, Sainsbury CAR, Jones GC Journal of Diabetes Nursing 20 (7): 238-243
2015 Capillary blood glucose monitoring, inpatient hypoglycaemia and quality of care GC Jones, CG Perry, A Monaghan, B Kennon, CAR Sainsbury British Journal of Diabetes 15 (1), 24-26 (pdf)
2015 Comment on ‘A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure’ GC Jones, CAR Sainsbury Diabetic Medicine 32 (2), 287-287
2015 Longitudinal Blood Pressure Control, Long-Term Mortality, and Predictive Utility of Serum Liver Enzymes and Bilirubin in Hypertensive Patients. L McCallum, J Panniyammakal, CE Hastie, J Hewitt, R Patel, GC Jones, S Muir, M Walters, N Sattar, AF Dominiczak, S Padmanabhan Hypertension 66 (1), 37-43 (pdf)
2014 Trends in recorded capillary blood glucose and hypoglycaemia in hospitalised patients with diabetes GC Jones, H Casey, CG Perry, B Kennon, CAR Sainsbury. Diabetes research and clinical practice 104 (1), 79-83
2014 Dipeptidyl peptidase 4 inhibitors in routine clinical practice: experiences from a Scottish teaching hospital AL Brown, CR Sainsbury, C Fenelon, AB Mullen, GC Jones British Journal of Diabetes 14 (4), 134-137 (pdf)
2014 Numerical simulation of blood flow and pressure drop in the pulmonary arterial and venous circulation MU Qureshi, GDA Vaughan, C Sainsbury, M Johnson, CS Peskin, MS Olufsen, NA Hill Biomechanics and modeling in mechanobiology 13 (5), 1137-1154
2013 Long-Term and Ultra Long–Term Blood Pressure Variability During Follow-Up and Mortality in 14 522 Patients With Hypertension. CE Hastie, P Jeemon, H Coleman, L McCallum, R Patel, J Dawson, W Sloan, P Meredith, GC Jones, S Muir, M Walters, AF Dominiczak, D Morrison, GT McInnes, S Padmanabhan Hypertension 62 (4), 698-705 (pdf)
2012 Rarefaction and blood pressure in systemic and pulmonary arteries MS Olufsen, NA Hill, GDA Vaughan, C Sainsbury, M Johnson Journal of fluid mechanics 705, 280-305
2012 Hematocrit Predicts Long-Term Mortality in a Nonlinear and Sex-Specific Manner in Hypertensive AdultsNovelty and Significance L Paul, P Jeemon, J Hewitt, L McCallum, P Higgins, M Walters, J McClure, … Hypertension 60 (3), 631-638
2012 Boerhaave’s syndrome and diabetic ketoacidosis K Mitchell, G Jones Practical Diabetes 29 (7), 268-268
2011 AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study JG Boyle, PJ Logan, GC Jones, M Small, N Sattar, JMC Connell, … Diabetologia 54 (7), 1799-1809
2019 Predicting mortality in both diabetes and open source clinical datasets from free text entries using machine learning (natural language processing) | Diabetes Technology Society. November 2019. Washington DC | .pdf
2019 personalising risk prediction in diabetes using machine learning bridging the gap between RCT and RCD | Royal College of Physicians and Surgeons (Glasgow) | May 2019. Glasgow | .pdf
2019 data landscape presentation. march 2019 | .pdf
2018 Machine learning approaches to (i) predicting response to therapy in diabetes, (ii) data-driven diabetes subtype classification and (iii) synthetic data generation. Dundee. 210618 | .pdf | .ppt
2018 Machine-Learning (neural network) driven algorithmic classification of Type 1 or Type 2 diabetes at the time of presentation significantly outperforms experienced clinician classification. DUK. London | .pdf
2018 Parallel time-series analysis of HbA1c and Systolic BP using a recurrent neural network (RNN) stratifies for 1-year mortality in Type 2 Diabetes independent of age and parameter variability. DUK. London | .pdf
2018 Parallel time-series analysis of HbA1c, Systolic Blood Pressure and BMI using Recurrent Neural Networks stratifies for 1-year mortality in T2DM, independent of age and parameter variability. ATTD. Vienna | .pdf
2018 Time-series analysis of HbA1c using Recurrent Neural Networks stratifies for 1-year mortality in Type 1 and Type 2 Diabetes, independent of age and variability. ATTD. Vienna | .pdf
2017 MyDiabetesIQ. machine learning for decision support & outcome prediction in diabetes. Automated Clinical Epidemiology Studies workshop, University of Birmingham. 141217 | .pdf
2017 Diabetes and opiate replacement therapy (ORT). A retrospective cohort study of health care usage and clinical outcomes. H Druce, D Morrison, C Sainsbury, R Lowrie, C Ritchie, GC Jones. Oral Presentation. RCGP, London | .pdf
2017 Glucose dynamics and mortality in RRT patients: an initial report. Matthew A Rutherford, Gregory C Jones, Alan G Jardine, Patrick B Mark, Peter C Thomson, Christopher AR Sainsbury. Oral Presentation, SRA, Dunblane 2017 | .pdf
2017 Diabetes and opiate replacement therapy (ORT). A retrospective cohort study of healthcare usage and clinical outcomes. H Druce, R Lowrie, C Ritchie, D Morrison, CAR Sainsbury, GC Jones. Poster Presentation, EASD, Lisbon 2017 | .pdf
2017 Serum chloride predicts mortality risk in type 2 diabetes – analysis of 91,159 patients from the West of Scotland. Linsay McCallum, Christopher A Sainsbury, Gregory C Jones, Sandosh Padmanabhan. AHA, 2017 | .pdf
2017 Serum chloride is a mortality risk predictor in type 2 diabetes mellitus – analysis of 91,159 patients in the West of Scotland. Linsay McCallum, Christopher A Sainsbury Gregory C Jones, Sandosh Padmanabhan. Oral Presentation, ESH, Milan 2017 | .pdf
2017 Non-stimulated c-peptide is independently associated with requirement at 1 year for insulin therapy in paitnets with diabetes. A retrospective cohort study of 872 patients. EL Leighton, K Smith, SG Cunningham, CAR Sainsbury, GC Jones. Poster Presentation, ECE, Lisbon 2017 | .pdf
2017 Admission Glucose Number (AGN): a novel score associated with adverse outcomes in patients admitted with Type 2 Diabetes. CAR Sainsbury, SG Cunningham, R Srivastava, GC Jones. Poster Presentation. Diabetes UK, Manchester 2017 | .pdf
2017 Glucose variability and risk of hypoglycaemia amongst inpatients with type 2 diabetes and its relationship to drug class exposure. KM Fairhurst, SG Cunningham, CAR Sainsbury, GC Jones. Poster Presentation. Diabetes UK, Manchester 2017 | .pdf
2017 Does pre-admission HbA1c predict inpatient glucose characteristics and outcomes in patients with diabetes? M Talla, SG Cunningham, CAR Sainsbury, GC Jones. Poster Presentation. Diabetes UK. Manchester March 2017 | .pdf
2017 Admission Glucose Number (AGN): A novel point-of-admission score associated with prolonged admission duration, and with glycaemic characteristics in patients with Type 1 Diabetes. R Maitland, R Srivastava, S Cunningham, G Jones, C Sainsbury. 2017. ATTD, Paris. Oral Presentation | .pdf
2016 Does type of diabetes, and treatment prescribed prior to admission influence quality of treatment of inpatient hypoglycaemia? CAR Sainsbury, J Khan, GC Jones. British Endocrine Society. Oral Presentation | .pdf